The phenomenon of transgenderism not only provokes reactions, but inevitably raises questions – questions about what is real and questions about what is moral. The reality question boils down to this: Is it really the case that a person can be born with “the wrong body,” or is the person who feels this way simply confused at the level of their mind? The morality question follows on from this, but has numerous faces to it, as well as various legal implications. Perhaps understandably, differing answers to these questions tend to polarise people. This essay explores how we can we understand the transgender revolution from a Biblical perspective.